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Myth vs Fact on the The National Toxicology Program Cell Phone Cancer Study

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23 Myths About the National Toxicology Program Cell Phone Radiation Cancer Study
Correcting the Misinformation

 

Note: This webpage was created in response to the June 2016 NTP release. It has not yet been updated for the 2018 NTP draft technical report release.

The National Toxicology Program (NTP) study found an association between cell phone radiation and cancer prompting an astonishing chorus of criticism from almost every prominent media outlet in the country.

Environmental Health Trust analyzed the media response and found a pattern of consistent inaccurate and misleading statements repeated over and over again in literally hundreds of news articles. Most of the criticisms levied at the NTP findings are inaccurate and simply do not hold up to scientific scrutiny.

We have counted a total of 23 myths. Sometimes they are quotes and sometimes they are the journalists statements. Either way, the more such false facts are put forth without scientific response, the more DOUBT is perpetuated. These myths inaccurately portray the NTP study and allow the important results to be downplayed.

Please take the time to inform yourself of the FACTS about the study.

23 Myths About the National Toxicology Program Cell Phone Radiation Study

Click on the Myth below

Overarching Myth #1:
The NTP study is just one rat study that is irrelevant to humans because the radiation exposures were far higher than humans get from cell phones.

Fact:
This is the world’s largest, most carefully done study on wireless radiation specifically designed to mimic human exposures in rodents. Every agent that is known to cause cancer in humans has been shown to be carcinogenic in animals when adequately tested.

Cell Phone Cancer Study“The researchers treated the rats to very heavy amounts of radiation — nine hours a day, seven days a week — which is far more than most people spend holding their cellphones to their heads. (Many people nowadays rarely hold their cellphones up to their heads at all.)”

Brad Plumer in ‘Seriously, stop with the irresponsible reporting on cellphones and cancer’, The VOX, May 27, 2016 

“Cellphones probably cause cancer if the exposure is close enough, long enough, and in sufficient magnitude. We don’t yet know the risk for a given level of exposure in humans. We need more data in this area, not only for cellphones, but for bluetooth devices, wifi and all the other RF-EMF devices out there. Until then, reduce your exposure whenever possible.”

–Christopher J. Portier and Wendy L. Leonard, Scientific American, June 13, 2016

Myth: The NTP rats radiation exposure was way too high to be relevant to human health.

Fact: The NTP study was designed to mimic long term human exposure to cell phone radiation and to test the adequacy of safety limits.

  • The NTP study had three radio frequency radiation exposure levels which were 1.5 W/kg, 3 W/kg, and 6.0 W/kg. These radiation exposures are the same and only slightly higher than a person gets while using a cell phone to the head. For comparison the US FCC exposure limit for cell phones is 1.6 W/kg (about the same as the first exposure group) and the FCC limit for extremities such as the arms, legs and ears- the limit is 4.0 W/kg (more than the second exposure group).  The 6.0 W/kg was a level that is not even twice what we allow to our arms and legs.
  • This study was designed to test if government safety limits (which only protect us from thermal radiation levels) are protective of human health and the NTP findings indicate these limits are not protective.
  • The exposures of the brain in the NTP study were not very different from human exposures associated with use of cell phones.
  • It is standard practice for rodent studies to have experimental groups with higher exposure levels than average human exposure in carcinogenicity studies.
  • Many teens sleep with their cell phones and people most commonly hold phones against their ears and body, while cell phone manufacturers and carriers have resisted efforts to warn people not to do so.
Click here for a full explanation
Myth: The NTP rats radiation exposure was way too high to be relevant to human health.

Fact: The NTP study was designed to mimic long term human exposure to cell phone radiation and to test the adequacy of safety limits. It is standard practice for rodent studies to have experimental groups with higher exposure levels than average human exposure in carcinogenicity studies.

  • The radiation exposure groups were at three levels comparable to human exposures to cell phone radiation. The NTP study had three radio frequency radiation exposure levels which were 1.5 W/kg, 3 W/kg, and 6.0 W/kg. These radiation exposures are the same and only slightly higher than a person gets while using a cell phone to the head. For comparison the US FCC exposure limit for cell phones is 1.6 W/kg (about the same as the first exposure group) and the FCC limit for extremities such as the arms, legs and ears- the limit is 4.0 W/kg (more than the second exposure group).  The 6.0 W/kg was a level that is not even twice what we allow to our arms and legs.Some statements have been made that “ The RF exposure levels tested in the study were 19 to 75 times higher than the human exposure limits.” (Health Canada). This is not a relevant comparison nor a useful framework to understand the exposure.The  local tissue SAR is the important dose to understand for assessing human risk – not the whole body SAR. While it is true that the Federal Communications Commission (FCC) has set an exposure limit to RFR whole body SAR of 0.08 W/kg averaged over the whole body, the localized exposure limits- the local tissue SAR-  set by the FCC and Health Canada  for cellphones (as detailed above) is 1.6 W/kg averaged over any one gram of tissue for the brain (and 4.0 W/kg for extremities). In Europe the localized tissue SAR for cell phones is 2.0 W/kg.

    In response to the statement by Health Canada, Dr. Ronald Melnick, the US NIH scientist  who led the NTP study design responded, “For a cell phone held next to the body, no single gram of tissue should be exposed to 1.6 W/kg or greater per FCC regulations. The tissue with highest exposure is that which is closest to the antenna. That is why the exposure intensity to the brain is most critical for cell phone users who hold their phones next to their head. In the NTP study, exposure to the brain was similar to exposure to other organs of the body as well as the whole body – this is because animals were exposed in reverberation chambers where exposures were coming from multiple angles. Consider the alternative: what if the whole body exposure in the NTP study was 0.08 W/kg and the brain was also exposed to 0.08 W/kg! In that case, exposure to the brain would be approximately 20 to 75 times LOWER than the FCC limit. If we are concerned about potential risk to the brain, it makes no sense to expose animals to RFR at levels that are much lower than what humans receive when using their cell phones. The same argument holds for other organs of the body. The dosimetry for any body tissue is dependent on its proximity to the cell phone antenna, i.e., the local tissue SAR is the important dose for assessing human risk – not the whole body SAR.

    The government of France regularly tests their cell phones and found that 90% violated the regulatory limits of 2.0 W/kg when the cell phone was at body worn distance, meaning when cell phones were placed directly on the body such as in a bra or tight in pants pocket, the radiation absorbed. (Read about the French government testing here). In addition, a 2017 CBC Report tested three of the most popular cell phones in a US lab and found all of the tested phones failed the test and exceeded regulatory limits when tested directly against the body.

  • This study was designed to test if government safety limits (which only protect us from thermal radiation levels) are protective. The results indicate that adverse carcinogenic effects occur at non-thermal (non-heating) levels which means that safety is not assured even if one abides by government regulations. Government  regulations for microwave radiation  are based on the assumption that “if it does not heat you, it will not hurt you.” To test the “no-heating” cut-off for harm, NTP animals were exposed up to almost the maximum dose they could tolerate with no increase in body temperature. The animals in this experiment never experienced an increase in body temperature over one degree Celsius, as this is considered the cut-off point for heating effects. Despite this limit, male rats developed increased cancers compared to controls and a dose response was observed with respect to the schwannoma rate. The most important thing to know about the NTP radiation exposures is that the radiation dose in the study did not cause a measurable increase in the animal’s body temperature but still found a carcinogenic effect. This indicates that government safety need to be strengthened to include protection from biological effects found at non-thermal levels.
  • The NTP study was specifically “designed specifically to mimic the human exposure scenario” and to account for the increased use of technology in the future.  Listen to NIH scientists discuss the exposure set up stating, “Our studies are designed specifically to mimic the human exposure scenario. The NTP studies are looking at exposures for 10 hours a day. There’s heavy cell phone users that may approach the 10 hour mark – that may be excessive, but it allows us to fully investigate whether or not there is an effect of cell phone frequency radiation.”
  • The exposures of the brain in the NTP study were not very different from human exposures associated with use of cell phones. Lawyers and real estate agents are examples of many people who are on their cell phone for many hours every day. In the carefully designed NTP exposure system, animals were exposed to radiation in special reverberation chambers, with whole body specific absorption rates (SAR) values at 1.5, 3, and 6.0 W/kg. Specific absorption rates (SAR), are measures of the rate of RF energy absorbed per unit mass of tissue. With respect to exposures to the brain, SAR values in rats were similar to or slightly higher than human exposures from cell phones held next to the head. In the US, the localized FCC exposure limit for cell phones is 1.6 W/kg averaged over any one gram of tissue when considering the brain (in Europe it is higher at 2 W/kg) and for extremities such as the arms, legs and ears- the limit is 4.0 W/kg.
  • It is standard practice for rodent studies to have higher exposure levels than average human exposure. Mice and rats have far shorter life spans than humans. Rodents only live up to 3 years whereas humans can live up to 100 years. To identify a hazardous agent, exposure levels in animal studies are often much higher than human exposures, while lower doses are included for analyses of dose-response relationships. The NTP study of RFR could not use exposure intensities much higher than that of cell phones in order to prevent any measurable increases in body temperature. Consequently, the duration of exposure was extended to nine hours a day for 106 weeks or less. The cumulative total exposure is comparable to thirty-six years of exposure (and children given a phone in middle school will have many more years of exposure than that) at a rate of 30 minutes per day, hardly excessive.

People most commonly hold phones against their ears and are often exposed 24 hours to RF-EMF. The statement “Many people nowadays rarely hold their cellphones up to their heads at all,” is simply false. Many people have given up their landline and only use cell phones. All one has to do is stand outside in a public place such as a subway terminal and watch numerous people walk by with the cell phone up to their head. Real estate agents, lawyers, healthcare workers and even retail store employees  are occupations where wireless technology is used for hours a day with devices carried on or against the body. It is a fact that many teenagers sleep with their phones at their pillow and carry their phones on their body all day long. Furthermore, cell tower and cell antennae placements are only increasing nationwide with the rollout of 5 G and newer technologies- exposing the population to higher levels and a variety of different frequencies.

In the US, the localized exposure limit for cell phones is 1.6 W/kg averaged over any one gram of tissue. In Europe, it is 2 W/kg averaged over 10 grams of tissue. These exposure values, which are referred to as specific absorption rates (SAR), are measures of the rate of RF energy absorbed per unit mass of tissue. When an individual uses a cell phone and holds it next to his or her head, exposure to the brain will be much higher than exposures to other parts of the body. Body tissues located nearest to the cell phone antenna receive much higher exposures than tissues located distant from the antenna. When considering organ-specific risk (e.g., risk to the brain), the important measure of exposure is the 1.6 W/kg value in any gram of tissue in that organ. Individual manufacturers and the FCC provide SAR values for cell phone emissions. While some cell phones emit lower radiation levels, other phones emit radiation that can produce an SAR dose near or above 1.5 W/kg.

Cell Phone Cancer Study“Let’s begin with the fact that this is a rat study and that we shouldn’t jump to the conclusion that what happens with rats and cancer is what happens in humans.”

–Aaron Carroll in “Why It’s Not Time to Panic About Cell Phones and Cancer”, The New York Times, May 31, 2016

Myth: Rat research does not inform human health risk.

Fact: Rat research does inform human health risk.

  • Rats are the preferred animal model for carcinogenicity studies.
  • Regulatory agencies currently rely on rodent carcinogenicity bioassay data to predict whether or not a given chemical poses a carcinogenic threat to humans.

What happened in the NTP rats is, in fact, happening in humans as documented by scientific research.

Click here for a full explanation
Cell Phone Cancer Study“Let’s begin with the fact that this is a rat study and that we shouldn’t jump to the conclusion that what happens with rats and cancer is what happens in humans.”

–Aaron Carroll in “Why It’s Not Time to Panic About Cell Phones and Cancer”, The New York Times, May 31, 2016

Myth: Rat research does not inform human health risk.

Fact: Rat research does inform human health risk.

  • Rats are the preferred animal model for carcinogenicity studies. Carcinogenicity studies in rodents are important for several reasons: (1) animals and humans exhibit similarities in the biological processes of disease induction – this is why animal models are used in preclinical trials of new pharmaceutical agents, (2) it is unethical to intentionally expose humans to known hazardous agents, (3) every agent that is known to cause cancer in humans is carcinogenic in animals when adequately tested (IARC, preamble), and (4) almost one-third of human carcinogens were identified after carcinogenic effects were found in well-conducted animal studies (Huff, 1993, Chemicals and cancer in humans: first evidence in experimental animals, Environmental Health Perspectives 100:201-210). Read FDA guidance.
  • Regulatory agencies currently rely on rodent carcinogenicity bioassay data to predict whether or not a given chemical poses a carcinogenic threat to humans. There are strong correlations of the carcinogenic potencies between rats and mice, and the upper limits on potencies in humans are consistent with rodent potencies for chemicals on which human exposure data are available. In 1999, the U.S. Food And Drug Administration (FDA) recommended that the National Toxicology Program initiate this large scale rodent study on radiofrequency and the 1999 FDA Report stated:
    • “Animal experiments are crucial because meaningful data will not be available from epidemiological studies for many years due to the long latency period between exposure to a carcinogen and the diagnosis of a tumor.
    • There is currently insufficient scientific basis for concluding either that wireless communication technologies are safe or that they pose a risk to millions of users. A significant research effort, including well-planned animal experiments, is needed to provide the basis to assess the risk to human health of wireless communications devices.”
  • What happened in the NTP rats is happening in humans. The rodent cells which developed tumors in the NTP rats are the same cells that display elevated tumor risk in human studies of long-term, heavy cellphone users. This correlation cannot be ignored and is precisely why the NIEHS/NTP released the results. At the May 27, 2016 NIEHS press conference when the report was released, Dr. John Bucher (NTP) stated, “The reason that we’re bringing these particular findings to the attention of the public today is the fact that they are in tumor sites, there’s tumor sites and types that have been identified in human studies – as I mentioned, the IARC human studies.”

“These results are particularly interesting in the light of the results of the INTERPHONE international study, which I had the opportunity to coordinate. The study included over 2,700 cases of glioma and 1,100 cases of schwannoma of the acoustic nerve and found evidence of an association between mobile phone use (as well as level of radiofrequency exposure) and increased risk of developing both types of tumours. “

–Elisabeth Cardis May 27, 2016 GROWING EVIDENCE FOR THE LINK BETWEEN MOBILE PHONES AND CANCER

logo ars technicaThe study, which was not properly peer reviewed—despite what some outlets have reported—is chock full of red flags: small sample sizes,…”

—Beth Mole in Study that found cell phones cause cancer in rats is riddled with red flags, ARS TECHNICA, May 31, 2016

Myth: The NTP study is just a small “single rat study.”

Fact: The $25 Million NTP study is the world’s largest most carefully done study ever done on long term wireless health risks.

  • They used double the usual number of animals required for this type of study.
  • The NTP convened not one but three panels to look at the abnormal tissues and determine if they were cancerous.
  • The NTP solicited unprecedented review from multiple scientists from outside the NTP to critically review all aspects of the data analysis and study findings.
Click here for a full explanation
logo ars technicaThe study, which was not properly peer reviewed—despite what some outlets have reported—is chock full of red flags: small sample sizes,…”

—Beth Mole in Study that found cell phones cause cancer in rats is riddled with red flags, ARS TECHNICA, May 31, 2016

Myth: The NTP study is just a small “single rat study.”

Fact: This is the largest study ever done on wireless health risks. Thousands of rodents were used in the NPT’s three-phased study design to ensure accuracy in exposure. First, pilot studies and subchronic studies were  conducted to determine the maximum intensity of cellphone radiation that could be employed without inducing any heating effect. Then, the final two-year chronic studies exposed rodents prenatally and for the majority of their lifetime (up to 24 months), utilizing the information from the pilot and subchronic studies. Unlike prior studies in which rodents were exposed in tubes or using a ferris wheel design, the NTP rodents were allowed to be roam free in their cages during exposure. This was permitted due to the elaborate underground reverberation system built in Switzerland. (Click here for slides showing the exposure set up.)

Double the usual number of rats were used. Usually 50 rodents are used per group in carcinogenicity studies but 90 were used for each group in the NTP study.  As the American Cancer Society states, “The NTP was given the difficult task of trying to answer important questions about the potential cancer risk posed by cell phones, and the group did not shirk from its responsibility. NTP staff were clearly aware of the potential importance of this study and went the extra distance to ensure the best science is used. They used double the number of animals required for this type of study; they convened not one but three panels to look at abnormal tissues from treated animals to ensure that what was identified as a brain and heart tumor was indeed a brain and heart tumor; they solicited review from multiple scientists from outside the NTP to critically review all aspects of the data analysis and study findings, to ensure the findings would stand up to the critical assessment expected once these unexpected findings were released.” Read the American Cancer Society Press Release here.

consumer health day“I suspect that this experiment is substantially underpowered and that the few positive results found reflect false positive findings” wrote outside reviewer Dr. Michael Lauer, deputy director of NIH’s office of extramural research.

—Healthday News in NIH Experts Cast Doubt on Rat Study Linking Cellphones, Tumors May 27, 2016

Myth: The NTP study was underpowered and statistically unable to detect a true effect.

Fact: A underpowered study is more likely to result in a false negative and the NTP researchers thoroughly address this issue in their analysis.

Click here for a full explanation
consumer health day“I suspect that this experiment is substantially underpowered and that the few positive results found reflect false positive findings” wrote outside reviewer Dr. Michael Lauer, deputy director of NIH’s office of extramural research.

—Healthday News in NIH Experts Cast Doubt on Rat Study Linking Cellphones, Tumors May 27, 2016

Myth: The NTP study was underpowered and statistically unable to detect a true effect.

Fact: A underpowered study is more likely to result in a false negative.

  • Having low statistical power means that there is a greater chance for a false negative rather than a false positive result. That is, there is a high probability of accepting the no-effect hypothesis even when a true effect exists.
    • Dr. Melnick responded to one of Dr Lauer’s statements in the Hebrew University Press conference that “One comment was made that the study had low statistical power and that might lead to a false positive. I’m not sure if that was a misstatement by the reviewer because low statistical power means there’s a high probability of accepting the null hypothesis even when a true effect may exist. That is, there is a greater chance for a false negative rather than a false positive if there is low statistical power.”
  • NTP scientists specifically addressed Dr. Lauer’s concerns about the power in the NTP Report section entitled NTP Comments on Statistical Issues Raised by the Reviewers page 67-74, the NTP responded in full.

On page 67:

“Although the NTP conducts statistical tests on multiple cancer endpoints in any given study, numerous authors have shown that the study-wide false positive rate does not greatly exceed 0.05 (Fears et al., 1977; Haseman, 1983; Office of Science and Technology Policy, 1985; Haseman, 1990; Haseman and Elwell, 1996; Lin and Rahman, 1998; Rahman and Lin, 2008; Kissling et al., 2014). One reason for this is that NTP’s carcinogenicity decisions are not based solely on statistics and in many instances statistically significant findings are not concluded to be due to the test agent. Many factors go into this determination including whether there were pre-neoplastic lesions, whether there was a dose-response relationship, biological plausibility, background rates and variability of the tumor, etc. Additionally, with rare tumors especially, the actual false positive rate of each individual test is well below 0.05, due to the discrete nature of the data, so the cumulative false positive rate from many such tests is less than person would expect by multiplying 0.05 by the number of tests conducted (Fears et al., 1977; Haseman, 1983; Kissling et al., 2015).”

On page 69 of NTP Comments on Statistical Issues Raised by the Reviewers the NTP states:

“Sample size calculations were conducted for this study. However, for detecting carcinogenesis, sample size and power will depend on the baseline (control) tumor rate and the expected magnitude of the increase in tumors. For example, at 80% power, sample size requirements will be quite different for detecting a 2-fold increase in a rare tumor having a spontaneous occurrence of 0.5% compared to 2-fold increase in a more common tumor having a spontaneous occurrence of 10%. Because many different tumor types having wide range of spontaneous occurrence are involved in these studies, there is no “one-size-fits-all” sample size; rather, the sample size is a compromise among several factors, including obtaining reasonable power to detect moderate to large increases for most tumor types, while staying within budgets of time, space, and funding. A sample of 90 animals per sex per group was selected as providing as much statistical power as possible across the spectrum of tumors, under the constraints imposed by the exposure system.

The NTP’s carcinogenicity studies are similar in structure to the OECD’s 45 Guideline for carcinogenicity studies and the FDA’s guidance for rodent carcinogenicity studies of pharmaceuticals. These guidelines recommend at least 50 animals of each sex per group, but also mention that an increase in group size provides relatively little increase in statistical power. In the NTP’s RFR studies, the group sizes were 90 animals of each sex per group, nearly twice as many as the minimum recommendation. Increasing the group sizes further provides diminishing returns, for which additional animals do not substantially increase power.

Page 70:

“It is true that the power is low for detecting moderate increases above a low background tumor rate of approximately – %, as was seen in the brain and heart tumors. However, this low power does not correspond to high risk of false positive findings. The paper by Ioannidis that was cited correctly states that when studies are small or effect sizes are small (i.e., statistical power is low), “the less likely the research findings are to be true.” Research findings can be “not true” if the result is a false positive or a false negative. With low statistical power, false negatives are much more likely than false positives. Therefore, the vast majority of false research findings in a low power situation will result from the failure to detect an effect when it exists. The false positive rate on any properly constructed statistical test will not exceed its significance level, alpha. By definition, the significance level of a statistical test is its false positive rate, and it is typically selected by the researcher, often at a low fixed value such as 0.05 or 5%.”

On page 74 Dr. Bucher again addresses the issue:

“Although Mike referred to the example of positive findings in underpowered epidemiology studies that could not be replicated in larger follow up studies, there is a growing literature alluding to this problem with respect to experimental animal studies as well. An example is a relatively recent article by one of our collaborators in CAMARADES, Malcolm MacLeod.

http://www.nature.com/news/2011/110928/full/477511a.html

It’s important to distinguish between low power to detect effects, and the constellation of other factors that often accompany low powered experimental animal studies in contributing to this problem. We’ve addressed this issue in a recent editorial, and these factors are captured in our published systematic review process for evaluating study quality in environmental health sciences (Rooney et al., 2014).

http://ehp.niehs.nih.gov/wp-content/uploads/122/7/ehp.1408671.pdf

http://ehp.niehs.nih.gov/wp-content/uploads/122/7/ehp.1307972.pdf

Table 1 in the Rooney et al. report outlines risk of bias considerations that commonly plague studies carried out by academic researchers that are accounted for in NTP studies.

I provide these examples to assure you that we are completely cognizant of these issues and take them very seriously. Again, we appreciate the help you’ve provided in assuring that we appropriately interpret and communicate our findings.

Best,

John Bucher

Overarching Myth 2: The weak and unusual study results prove the risk to humans is small and likely nonexistent.

Fact: When scientifically reviewed and statistically analyzed, the findings of statistically significant increased cancers and precancers in the exposed rats remain valid despite the gender and survival differences. Furthermore, the analysis is strengthened by the findings of other adverse effects from exposure such as lower birth rate and cardiac abnormalities.

new york times logo“Oddly enough, the incidence of tumors in females was minimal, barely different from the control group. It is not clear why the results would vary between the sexes, which is one reason some experts are questioning the findings.”

—Andrew Pollack in ‘Questions and Answers on the New Study Linking Cellphones and Cancer in Rats’, International New York Times, May 27, 2016

Myth: Cancer rates were only increased in the male rats but were not equally increased in females so the findings are questionable.

Fact: It is extremely common for males to show different cancer rates from females in both (NTP) laboratory studies and in epidemiological studies. Specifically, in previous NTP toxicology studies,  male rats as compared to females had more than ten times the incidence of malignant gliomas (brain tumors) and more than twice the rate of malignant schwannoma of the heart.

  • These rare tumors were observed only in RFR-exposed animals of both sexes while no tumors were observed in the control animals.
  • Female RFR-exposed animals did have higher rates than controls even if the possibility that this was not a chance occurrence could not be excluded with the desired probability.
  • The fact that we saw any of these tumors in the exposed females but none in the concurrent controls adds support to the conclusion that cell phone radiation leads to cancer among rats.
Click here for a full explanation
new york times logo“Oddly enough, the incidence of tumors in females was minimal, barely different from the control group. It is not clear why the results would vary between the sexes, which is one reason some experts are questioning the findings.”

—Andrew Pollack in ‘Questions and Answers on the New Study Linking Cellphones and Cancer in Rats’, International New York Times, May 27, 2016

Myth: Cancer rates were only increased in the male rats but were not equally increased in females so the findings are questionable.

Fact:

  • It is extremely common for males to show different cancer rates from females in both laboratory and epidemiological studies with men usually having higher rates. Specifically, in previous NTP toxicology studies,  male rats as compared to females had more than ten times the incidence of malignant gliomas (brain tumors) and more than twice the rate of malignant schwannoma of the heart. These statistics called “historical control incidence” are documented in the NTP report (Tables 1-6). As the American Cancer Society explains in their statement about the NTP results, “It’s important to note that these sorts of gender differences often appear in carcinogenic studies, so the fact they show up here should not detract from the importance of the findings.”
  • While the tumor incidence was greater in exposed male rats than in female rats, these rare and uncommon tumors were observed only in RFR-exposed animals of both sexes while no tumors were observed in the control animals. In addition, pre-cancerous lesions (glial hyperplasia and Schwann cell hyperplasia) were observed only in RFR-exposed male and female rats. Numerical differences are commonly detected between the sexes in animal carcinogenicity studies as well as in human populations. For example, brain cancer mortality rates are approximately 50% higher in men than in women, and for many human cancers (e.g., colon-rectal, liver, soft tissue including heart, kidney, non-Hodgkin lymphoma, etc.) the incidence and mortality rates are much higher in men than in women.
  • Female RFR-exposed animals did have higher rates than controls although it did not reach statistical signifigance. Seven exposed female rats had cancer or precancerous lesions in the glial cells and nine had cancer or precancerous lesions in their Schwann cells. Rates of cancer or precancerous lesions within the unexposed female rats were zero in the heart nerve and brain. Historically, female rats have much lower rates of both types of cancer. If we compare cancer rates among exposed female rats to historical controls (the average from studies of other exposures), RFR-exposed females developed 3.1 times the rate of gliomas and 1.9 times the rate of Schwannoma. It is essential to remember that not statistically significant does not equate to “no difference”. Exposed groups in the NTP study had higher rates of disease in every one of these cases. However, the differences were not high enough to allow researchers to reject the notion that these were chance occurrences with 95% certainty.
  • The different response rate between male and female rats in the RFR study does not alter the relevance of the cancer findings from this study.
“It is not surprising that the exposed males had more tumors than the females given what we have seen in the historical controls. But we can go one step further, the fact that we saw any of these tumors in the exposed females but none in the concurrent controls adds support to the conclusion that cell phone radiation leads to cancer among rats.” Ron Melnick

nymag“…the rats in the cell-phone-radiation group got these cancers at the rates they were supposed to. …It sounds as though if the control group had developed these cancers at the normal levels, there wouldn’t have been much to report here at all.”

—Jesse Singal in ‘For the Love of God, Please Chill Out About That New Study About Rats and Cell Phones and Cancer’, New York Magazine, May 27, 2016

Myth: If the control group had developed cancer at the usual rate (historical controls), there would be no statistically significant difference.

Fact: The concurrent controls in any given given experiment are always the best controls and the most important to consider as every detail of feed, housing and environment are truly identical.

  • NTP scientists carefully considered the issue of historical controls and factored it into their analysis.
  • An analysis comparing all controls—historic and present—with all exposed animals in the present study still shows a consistently increased probability of developing cancer.
Click here for a full explanation
nymag“…the rats in the cell-phone-radiation group got these cancers at the rates they were supposed to. …It sounds as though if the control group had developed these cancers at the normal levels, there wouldn’t have been much to report here at all.”

—Jesse Singal in ‘For the Love of God, Please Chill Out About That New Study About Rats and Cell Phones and Cancer’, New York Magazine, May 27, 2016

Myth: If the control group had developed cancer at the usual rate (historical controls), there would be no statistically significant difference.

Fact:

  • The concurrent controls are the best controls and the most important to consider in any given study. The fundamental concept behind a controlled experimental study is that the control group matches the exposed group as closely as possible as every detail of feed, housing and environment are truly identical. If all groups of rats are treated the same in the same experiment and only the exposed group has a statistically significant effect, then the statistical analysis calculates the probability that chance caused the observed differences by making the control rates artificially low or the exposed rates artificially high.
  • NTP scientists carefully considered the issue of historical controls and factored it into their analysis. Please listen to Dr. Michael Wyde, lead investigator of the National Toxicology Program study and Dr. Birnbaum, director of the National Institute of Environmental Health Sciences (NIEHS) of the National Institutes of Health specifically explain how this concern is invalid and does not detract from the findings in a video of a June 15, 2016 presentation of the NTP study. Dr. Birnbaum explains how the historical data was considered in the final analysis and she also points out that prior studies with this rat strain are limited and were under different conditions than in the NTP study. The NTP study on RFR was unique in that no other chronic study housed rats in individual cages (including controls) in reverberation chambers and only one other NTP study (but in a different strain of rats) was conducted in the laboratory where the RFR studies were performed. The reverberation chambers used in the NTP study were fully shielded from external electromagnetic fields.  No data are available to evaluate the impact of these unique circumstances on tumor rates in control animals.
  • An analysis comparing all controls—historic and present—with all exposed animals in the present study still shows a consistently increased probability of developing cancer. The argument that  “if the control group had developed these cancers at the normal levels, there wouldn’t have been much to report here at all” simply does not hold up to scientific scrutiny.

new yahoo logo“It shows us that there is a link between cellphone radiation and cancer, which is important. But it also implies that there’s a safe level of cellphone radiation, which is somewhere below having a cell phone glued to your ear for nine hours a day, seven days a week.”

Chris Mills in ‘Your cellphone is not giving you cancer’, Yahoo News, May 27, 2016

Myth: Since only the rats exposed to super high radiation levels had increased cancer, it must be perfectly safe to use our cell phones which emit a “safe” level of radiation.

Fact: No safe level has been scientifically documented as this study was not designed to determine a safe level.

  • Testing for the absence of an effect requires a completely different study design and uses different methods of statistical analysis than were employed in the NTP study.
  • Adequate research to determine a safe level of radiofrequency has not been performed by the US Government as of yet.
  • This study confirms that safety is not assured at levels the US government previously assumed were safe.
  • This study lends support to research findings that adverse biological effects from wireless radiation are found at radiation levels thousands of times lower than government safety limits.
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new yahoo logo“It shows us that there is a link between cellphone radiation and cancer, which is important. But it also implies that there’s a safe level of cellphone radiation, which is somewhere below having a cell phone glued to your ear for nine hours a day, seven days a week.”

Chris Mills in ‘Your cellphone is not giving you cancer’, Yahoo News, May 27, 2016

Myth: Since only the rats exposed to super high radiation levels had increased cancer, it must be perfectly safe to use our cell phones which emit a “safe” level of radiation.

Fact:

  • Testing for the absence of an effect requires a completely different study design and uses different methods of statistical analysis than were employed in the NTP study. Moreover, any discussion of safe exposure levels is not supported by the data. Such safety inferences have no scientific basis. The NTP study was not designed to determine a safe exposure level, but rather was setup to determine if non-heating levels could induce cancer and/or a toxic effect.
  • Adequate research to determine a safe level of radiofrequency has not been performed by the US Government as of yet. As of today, not a single US health and safety agency has determined a “safe” level of wireless radiation. Decades ago, the EPA initiated research and was set to issue standards when it was abruptly defunded in 1996 (see timeline below). Contrary to a widely held belief that premarket safety testing was done, in fact, long term safety testing for cell phones and wireless devices was never done. The NTP study was initiated for this very reason.
  • Biological effects from wireless radiation are found at radiation levels thousands of times lower than government safety limits and some studies also report adverse effects even after very short time periods of exposure. For example, after only 50 minutes of cell phone radiation exposure, cell phone radiation caused an increase in glucose metabolism in the human brain in a 2011 NIH US government study.  In a series of studies performed by Dr. Suleyman Kaplan’s team, damage to brain cells occurred after cell phone radiation exposures of one hour a day for one month. A research review published in Electromagnetic Biology and Medicine found that among 100 peer-reviewed papers “93 confirmed that RFR induces oxidative effects in biological systems”. Long term oxidative stress is known to be related to immune and inflammatory responses, carcinogenesis and metastasis, reproductive damage and even neurological diseases. 
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    “The tumors selected (gliomas, hyperplasias, and schwannomas) occur in later life and control rats did not live long enough to develop them. In fact, none of the control rats developed even one of these tumors!”

    —John D. Boice, Jr., Health Physics News, The Buster Report #49 

    Myth: The lower survival rate of the control group skewed the results because the control group did not live long enough to develop tumors.  

    Fact: NTP scientists carefully considered this question and there was no statistical difference in survival between control male rats and the exposed group of male rats with the highest incidence of gliomas and heart schwannomas. Therefore, survival was sufficient to detect tumors or precancerous lesions in control male rats.

    Click here for a full explanation

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    “The tumors selected (gliomas, hyperplasias, and schwannomas) occur in later life and control rats did not live long enough to develop them. In fact, none of the control rats developed even one of these tumors!”

    —John D. Boice, Jr., Health Physics News, The Buster Report #49 

    Myth: The lower survival rate of the control group skewed the results because the control group did not live long enough to develop tumors.  

    Fact:

    • There was no statistical difference in survival between control male rats and the exposed group of male rats with the highest incidence of gliomas and heart schwannomas. At week- 93 of the 2-year study, survival was exactly the same in that exposure group and in control male rats. Second, no glial cell hyperplasias (potential precancerous lesions in the brain) or heart schwannomas were observed in any control rat, even though glial cell hyperplasia was detected as early as week 58 and heart schwannomas were detected as early as week 70 in exposed rats. Thus, survival was sufficient to detect tumors or precancerous lesions in control male rats
    • NTP scientists carefully considered this question in their analysis. If the control rats were going to develop tumors, these precancerous lesions and tumors would have already been present. Yet not a single control had any evidence of an effect.

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    “There was little effect on the newborn rats, except the pups appeared to be very slightly lighter when the mothers were exposed to the signals.”

    —Maggie Fox, “A Possible Cellphone Link to Cancer? A Rat Study Launches New Debate”, NBC News, 27 May 2016

    Myth: The other effects found in the exposed rats such as decreased birthweight are trivial and irrelevant.

    Fact: The findings of a lower birth weight are an important indication of the adverse developmental impacts from prenatal exposure.

    Click here for a full explanation

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    “There was little effect on the newborn rats, except the pups appeared to be very slightly lighter when the mothers were exposed to the signals.”

    —Maggie Fox, “A Possible Cellphone Link to Cancer? A Rat Study Launches New Debate”, NBC News, 27 May 2016

    Myth: The other effects found in the exposed rats such as decreased birthweight are trivial and irrelevant.

    Fact: Low birth weight is not a trivial effect.

    • Low birth weight is not a trivial effect because it indicates adverse developmental impacts from prenatal exposure. Smoking during pregnancy also reduces birthweight.  Low birthweight is a well known result of toxic prenatal exposures to humans as well as rats. In humans, low birth weight is a risk factor for a variety of other health problems later in life.
    • If birthweight was stunted then what other developmental processes were stunted? Significant experimental research has shown that radio frequency exposure at legal levels damages brain neurons in prenatally exposed rats. The NTP study was not set up to investigate impacts on nervous system development so this information is not available from the NTP study. When it comes to the lower birthweight of NTP rodents, this effect constitutes an important signal that non thermal radiation levels can impair development.

    “Given the extremely large number of people who use wireless communication devices, even a very small increase in the incidence of disease resulting from exposure to the RFR generated by those devices could have broad implications for public health.” —National Toxicology Program Report – Christopher J. Portier and Wendy L. Leonard, Scientific American, June 13, 2016

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    “The results are fairly weak and confounding ” and  “Readers should be aware how weak the results really are.”

    —Kenneth Foster in “Cellphone Radiation Linked to Cancer in Major Rat Study”, IEEE Spectrum, 27 May 2016 & in Foster’s comments below the IEEE article.

    Myth: The results are weak and confounding.

    Fact: A doubling or tripling of risk would never be considered “weak” considering the widespread use of cell phones by humans worldwide. Even a small risk could eventually result in a considerable number of these lethal tumours in the population.

    • The results are strong, especially for the heart schwannomas.
    • Yes, it is true that a “low incidence” of tumors were found, but since these are rare tumors, the findings are quite significant.
    • DNA damage was induced with both modulations of radiofrequency radiation (RFR) in brains of both rats and mice.
    • Overall, one in 18 male rats exposed to cell phone radiation developed cancer and one in 12 male rats exposed to cell phone radiation developed cancer or precancerous cells.
    Click here for a full explanation

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    “The results are fairly weak and confounding ” and  “Readers should be aware how weak the results really are.”

    —Kenneth Foster in “Cellphone Radiation Linked to Cancer in Major Rat Study”, IEEE Spectrum, 27 May 2016 & in Foster’s comments below the IEEE article.

    Myth: The results are weak and confounding.

    Fact:

    • A doubling or tripling of risk would never be considered “weak”. In his statement, Foster has misused the term “confounding”. Lets consider the potential impact on humans. There are almost as many cell-phone subscriptions (6.8 billion) as there are people on this earth (7 billion). Even a small risk could eventually result in a considerable number of these lethal tumours. Studies carried out in Sweden indicate that those who begin using either cordless or mobile phones regularly before age 20 have greater than a 4-fold increased risk of ipsilateral glioma. If current young users of mobile phones face the risks shown in these case control studies, then several thousand new cases could develop annually in the U.S. alone.
    • The results are strong, especially for the heart schwannomas. In the heart, exposure to RFR in male rats resulted in a statistically significant, positive trend in the incidence of schwannomas. Positive trends for a greater number of tumors at higher doses were observed for both tumor types. Significantly more gliomas were seen in males exposed to CDMA (95% confidence level). Both the trends and the replication make these very strong results.
    • DNA damage was induced with both modulations of radiofrequency radiation (RFR) in brains of both rats and mice. In the frontal cortex of rats (CDMA) and mice (GSM and CDMA) the comet assay showed a genotoxic effect with a statistically significant trend and pairwise SAR-dependent increase.  How is DNA damage “weak”?
    • Yes, a “low incidence” of tumors were found, but since these are rare tumors, the findings are quite significant. Dr. Moskowitz cites these statistics which help to put it in perspective. :
      • Overall, one in 18 male rats exposed to cell phone radiation developed cancer- thirty of 540 (5.5%).
      • One in 12 male rats exposed to cell phone radiation developed cancer (glioma, schwannomas of the heart) or precancerous cells as compared to none of the 90 unexposed male rats- 46 of 540. Remember that 16 precancerous hyperplasias were diagnosed and these are known to develop into cancer in time. Had the study been a lifetime study, rather than a two year study, we likely would have marked these as cancers in the older rats. Rodents can live up to three years.
      • In the group exposed to the lowest intensity of cell phone radiation (1.5 W/kg), 12 of 180, or one in 15 male rats developed cancer or precancerous cells. In the highest exposure group (6 W/kg), 24 of 180, or one in 8 male rats developed cancer or precancerous cells.

    Bottom line: The results provide significant animal evidence that cell phone radiation can cause cancer and DNA damage. 

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    “There’s another oddity that’s received less attention: the alleged cancer link is modulation-dependent. It seems wildly improbable to The Register that the difference between CDMA and GSM modulation somehow triggers a different response in rat DNA.”

    Richard Chirgwin in “Rats revive phones-and-cancer scares: Study good for a headline, not much else”, The Register UK , May 30, 2016 

    Myth: The fact that CDMA rats had more of a response then  the GSM exposed rats makes no sense and shows the study is flawed.

    Fact: These findings are should not detract from the study findings.

    • It is scientifically understood that different modulations could have different biological impacts.
    • Such findings are consistent with recent analysis of epidemiologic studies  in humans which indicate that the more recent technologies  could have  a more dramatic biological effect, despite the lower power of the newer technology.
    • The health effects of various modulations is an important research area as indicated by prior research.
    Click here for a full explanation

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    “There’s another oddity that’s received less attention: the alleged cancer link is modulation-dependent. It seems wildly improbable to The Register that the difference between CDMA and GSM modulation somehow triggers a different response in rat DNA.”

    Richard Chirgwin in “Rats revive phones-and-cancer scares: Study good for a headline, not much else”, The Register UK , May 30, 2016 

    Response:

    • It is scientifically understood that different modulations could have different biological effects. Cellular communication signals are very complex. Radiofrequency radiation with different modulations and characteristics can produce different effects even though they may produce the same pattern of SAR distribution and tissue heating.
    • Such findings are consistent with the analysis by Swedish cancer researchers which found differences in human gliomas associated with different modulations of cell phone radiation. They found the lower power3G UMTS phones had a higher glioma (a type of brain cancer) risk than the higher power 2G GSM phones. More recent technologies appear to have more a more dramatic biological effect. Modulations are evolving to transmit more data faster at a given frequency, and this results in higher peak to average power ratios. In the lab, it is notable that experiments using real-life devices are much more likely to find significant effects.
    • The US Federal Interagency Workgroup raised this issue in a 1999 letter citing how research shows different biological responses to modulated RF radiation exposures as compared to unmodulated exposures. Read the Letter. Currently different modulations are in use that were never imagined decades ago when the original research was done to understand human health risk.
    • Decades of research has pointed to the importance of modulation in impacting human health. For example in 1994 a (U.S.) Air Force “Material Command, Rome Laboratory Radiofrequency / Microwave Radiation Biological Effects and Safety Standards: A Review” stated “It was recognized that the SAR does not encompass all of the important factors necessary to determine safe exposure levels. The modulation frequency and peak power of the incident EM field should also be considered. Some of the investigators warned that extra care should be taken by persons that are subjected to pulsed EM fields or by fields that are modulated near the whole-body resonance frequency.”
    • The NTP study was designed to study both modulations precisely because the researchers wanted to understand potential effects from the different modulations. 

    Overarching Myth #3: Because we don’t fully understand the biology behind these results we can ignore them.

    Fact: The NTP study confirms the existence of a non-thermal effect.   For almost every well established carcinogen ever identified, from cigarettes to asbestos, the evidence of risk preceded our understanding of the mechanism by many years, if not decades.

    science

    “There’s another oddity that’s received less attention: the alleged cancer link is modulation-dependent. It seems wildly improbable to The Register that the difference between CDMA and GSM modulation somehow triggers a different response in rat DNA.”

    Richard Chirgwin in “Rats revive phones-and-cancer scares: Study good for a headline, not much else”, The Register UK , May 30, 2016 

    Myth: There is no well understood mechanism by which cell phone radiation induces cancer so – regardless of the findings – there must be a lack of risk. The fact that CDMA rats had more of a response then the GSM exposed rats makes no sense and shows the study is flawed.

    Fact: The study indicates that a non-thermal mechanism clearly exists. The NTP provides strong evidence of a risk. Not fully understanding the mechanism  is not a basis to reject or to be suspicious of careful data observation and recording.

    • It could take decades – as it did with asbestos and smoking- before the mechanism is considered “proven”.
    • Several prominent scientists have published research highlighting sufficient evidence that radiofrequency radiation could result in biochemical changes that alter how our cells functions and increase the oxidative stress (increasing free radicals) in our bodies leading to chronic inflammation and cancer.
    Click here for a full explanation

    science

    “There’s another oddity that’s received less attention: the alleged cancer link is modulation-dependent. It seems wildly improbable to The Register that the difference between CDMA and GSM modulation somehow triggers a different response in rat DNA.”

    Richard Chirgwin in “Rats revive phones-and-cancer scares: Study good for a headline, not much else”, The Register UK , May 30, 2016 

    Myth: There is no well understood mechanism by which cell phone radiation induces cancer so – regardless of the findings- there must be a lack of risk.

    Fact: A proven mechanism is not necessary to understand data showing increased risk.

    • It is scientifically understood that different modulations could have different biological effects. Cellular communication signals are very complex. Radiofrequency radiation with different modulations and characteristics can produce different effects even though they may produce the same pattern of SAR distribution and tissue heating.  For example, there are two mechanistic studies which consider the effects of 2G and 3G signals. Statistical analysis in a study on human stem cells revealed that UMTS exposure had a stronger effect than GSM exposure (Markova et. al., 2010).  In an earlier study, an analysis of  impacts on the formation of DNA repair foci showed that effects were depend on carrier frequency (Belyaev et.al., 2009. These results are in line with the hypothesis that some signals may have higher biological impacts and possibly larger health risk effects than others.
    • The study indicates that a non-thermal mechanism clearly exists. The NTP study controlled for heating effects by making sure that the body temperatures of exposed rats did not increase by more than 1° C (1.9° F), suggesting that the cancers were triggered by some other mechanism.
    • It could take decades before the mechanism is considered “proven”. For almost every well established carcinogen ever identified, from cigarettes to asbestos, the evidence of risk preceded our understanding of the mechanism by many years, if not decades. The mechanisms by which smoking, for example, causes lung cancer were not established until the 1980’s – decades after the surgeon general began to warn of the massive cancer risks associated with smoking.
    • There is now sufficient evidence that radiofrequency radiation could result in biochemical changes that alter how our cells functions and increase the oxidative stress (increasing free radicals) in our bodies leading to chronic inflammation and cancer. Several prominent scientists have published (with full documentation) on the possible mechanisms by which cell phone/wireless radiation could result in increased cancer. They explain how long-term exposure to extremely low power levels of radiofrequency fields could initiate a series of biological effects with the end result of an increased risk for cancer and a myriad of other serious health effects.
    “Evidence of free-radical damage has been repeatedly documented among humans, animals, plants and microorganisms for both extremely low frequency (ELF) electromagnetic fields (EMF) and for radio frequency (RF) radiation, neither of which is ionizing. While IR directly damages DNA, NIR interferes with the oxidative repair mechanisms resulting in oxidative stress, damage to cellular components including DNA, and damage to cellular processes leading to cancer. Furthermore, free radical damage explains the increased cancer risks associated with mobile phone use, occupational exposure to NIR (ELF EMF and RFR), and residential exposure to power lines and RF transmitters including mobile phones, cell phone base stations, broadcast antennas, and radar installations”.
    • A 2016 published study Mechanism of low-level microwave radiation effect on nervous system (Hinrikus et al. 2016) aimed to explain the mechanism of the effect of low-level modulated microwave radiation on brain bioelectrical oscillations.
    “The proposed model of excitation by low-level microwave radiation bases on the influence of water polarization on hydrogen bonding forces between water molecules, caused by this the enhancement of diffusion and consequences on neurotransmitters transit time and neuron resting potential. Modulated microwave radiation causes periodic alteration of the neurophysiologic parameters and parametric excitation of brain bioelectric oscillations. The experiments to detect logical outcome of the mechanism on physiological level were carried out on 15 human volunteers.”
     

    Overarching Myth 4: Existing research invalidates the NTP findings of increased cancer and genotoxicity.

    Scientific Fact: The NTP study substantiates previous research findings from human and animal research indicating increased cancer risk and DNA impacts.

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    “Previous research in rodents has found that exposing animals to cell phone radiation across their entire bodies for only an hour a day or six hours a day for a shorter number of days did not lead to increases in the rates of lymphomas and brain tumors, respectively.”

    —Carina Storrs in “Cell phone radiation increases cancers in rats, but should we worry?”, CNN, May 27, 2016

    Myth: Previous animal research has not shown a link between cell phone radiation and cancer.

    Fact: Previous animal research has shown a link between cell phone radiation and cancer.

    • In fact, previous animal research has been replicated that indicates a carcinogenic effect, specifically cancer promotion.
    • A  U.S. Air Force study conducted in the early 1980’s found increased cancers in rats and previous studies have also shown DNA breaks.
    • The two small-scale studies cited in the CNN article are incomparable to the NTP study.
    Click here for a full explanation

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    “Previous research in rodents has found that exposing animals to cell phone radiation across their entire bodies for only an hour a day or six hours a day for a shorter number of days did not lead to increases in the rates of lymphomas and brain tumors, respectively.”

    —Carina Storrs in “Cell phone radiation increases cancers in rats, but should we worry?”, CNN, May 27, 2016

    Myth: Previous animal research has not shown a link between cell phone radiation and cancer.

    Fact: Previous animal research has shown a link between cell phone radiation and cancer.

    • In fact, previous animal studies are now replicated that indicate a carcinogenic effect, specifically cancer promotion. A 2015 study, which replicated a study done in 2010, found that weak cell phone signals can promote the growth of lymphomas, lung and liver tumors in mice. In 2013, the World Health Organization International Agency for the Research on Cancer specifically noted that “Four of six co-carcinogenesis studies showed increased cancer incidence after exposure to RF-EMF in combination with a known carcinogen”.
    • The two small-scale studies cited in the CNN article are incomparable to the NTP study. The 2006 “six hour a day” study cited by CNN was funded by Motorola and had an unusual set up in that the mice were sacrificed starting at 171 days (about 5.5 months) and the mice did not even live an entire year in the study. The “one hour a day” study cited was, well – one hour a day – and only followed animals for one and a half years. The life span of a rodent is approximately three years and the NTP study followed mice for a full two years to allow for a more adequate long term exposure. Importantly, the NTP study trumps all previous animal studies because no other animal study was as well designed and used such an elaborate set up.
    • A 5 year, $5 Million U.S. Air Force study conducted in the early 1980’s  found that significantly higher numbers of male rats exposed to low-intensity microwave radiation developed cancer in comparison to those not exposed. The Chou study exposed experimental animals to 2450 MHz,  which is similar to the frequencies used for WiFi, whereas the NTP study exposed rodents to 900 MHz and 1800 MHz microwave radiation. However in the Air Force Study, the rats’ average exposure was about 4-10 times lower than in the NTP study. Read more about this study in Dr. Moskowitz analysis. It is notable that in this study the researchers state, “Only male rats were used to minimize statistical variation, i.e., to avoid the hormonal variations characteristic of female rats. Use of female rats would have required a substantial increase in the number of animals.”
    • In the 1990’s, Henry Lai and V.J. Singh demonstrated that low levels of microwave radiation (2.45 GHz) well below that of cell phone radiation levels could increase the frequency of single-strand DNA breaks in the brain cells of live rats. The in-vitro studies of the $15 Million dollar REFLEX project lead by Franz Adlkofer also indicated a genotoxic effect of RF-EMFs at levels below proposed radiation safety levels.  In an June 2016 interview, Professor Adlkofer commented that  the NTP and Reflex study complement each other, and “intensify in their significance.”

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    “Despite the slew of headlines the study spurred, cancer researchers say one rat study doesn’t erase a patchy history of claims of a link between electric fields and cancer. Plus, there just isn’t any human data, and no increase in brain or heart tumors in people that should show up with hundreds of millions of them using cells phone, if there really was a link.”

    —Dan Vergano in “No, Your Cell Phone Probably Isn’t Giving You Cancer”, Buzzfeed, May 27, 2016

    Myth: There is no human evidence linking brain and heart tumors to cell phones.

    Fact: There is human evidence linking brain and heart tumors to cell phones.

    • Research on humans shows the same type of tumor increases -as seen in the rats- from long term RF-EMF radiation exposures.
    • The Swedish studies and the Interphone study not only found elevated glioblastomas, but also higher acoustic neuromas-  schwann cell tumors- at the highest level of cumulative call time.
    • These human studies provided the basis for the International Agency for Research on Cancer (IARC) classifying radiofrequency radiation as a Class 2B “possible” carcinogen in 2011.
    • NIEHS/NTP states, “Tumor types observed in this study are similar type to those observed in some epidemiology studies of cell phone users” and the study “Supports IARC conclusions of potential carcinogenic potential of RFR.”
    Click here for a full explanation

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    “Despite the slew of headlines the study spurred, cancer researchers say one rat study doesn’t erase a patchy history of claims of a link between electric fields and cancer. Plus, there just isn’t any human data, and no increase in brain or heart tumors in people that should show up with hundreds of millions of them using cells phone, if there really was a link.”

    —Dan Vergano in “No, Your Cell Phone Probably Isn’t Giving You Cancer”, Buzzfeed, May 27, 2016

    Myth: There is no human evidence linking brain and heart tumors to cell phones.

    Fact: There is human evidence linking brain and heart tumors to cell phones.

    • Human data does show the same type of tumor increases. The NTP finding of increased gliomas and schwann cell tumors of the heart in rats exposed to RFR is consistent with epidemiological reports of increases in gliomas and acoustic neuromas (schwann cell tumors) among humans exposed to cell phone radiation. Research studies that examined long term heavy cellphone users have found a statistically significant increase in glioblastomas (Coureau et. al., 2014, Hardell et al., 2014, Morgan et al, 2015,) The multi-country Interphone study published findings in 2010 and 2011 with results stating higher glioma risks in heavy users. In 2016 re-analysis of Interphone data found stronger positive associations to glioma risk among long term users and heavy users (Turner et al. 2016) and a statistically significant association between the intracranial distribution of gliomas and the self-reported (possible bias) location of the phone (Grell et al. 2016).
    • The Swedish studies and the Interphone study not only found elevated glioblastomas, but also higher acoustic neuromas, schwann cell tumors at the highest level of cumulative call time. The acoustic neuroma is also known as vestibular schwannoma, and it is a nonmalignant tumor of the 8th cranial nerve in humans. The NTP rats developed schwannomas- tumors of the nerve sheath but of the heart. Famous individuals diagnosed with an acoustic neuroma include Mark Ruffalo, Tara Subkoff, and Lucille Lewin.
    • “Human evidence” was a large part of the basis for the International Agency for Research on Cancer (IARC) classification of the cancer risk of radiofrequency radiation as a Class 2B “possible” carcinogen in 2011. The IARC expert working group noted research studies which indicated brain cancer risks were increased significantly after 10 years of cellphone use, and risk levels were greatest on the side of the head on which users held their cell phones. The Class 2B classification was based on “positive associations observed between exposure to radiofrequency radiation from wireless phones and glioma, and acoustic neuroma,” and for which a causal relationship was considered to be credible. Those associations were not considered to represent “sufficient evidence of carcinogenicity” at that time in 2011 because recall bias in the case-control studies could not be fully ruled out as a possible contributing factor.
    • NIEHS/NTP presented the results at the June 8, 2016 BioEM2016 Meeting, in Ghent, Belgium stating, “Tumor types observed in this study are similar type to those observed in some epidemiology studies of cell phone users” and the study “Supports IARC conclusions of potential carcinogenic potential of RFR.” (NTP BIOEM 2016 Powerpoint 27 of 32) 

    the new york times logo featured“Many studies have been conducted, including some very large ones like the Million Women Study in Britain, and a Danish study of more than 350,000 cellphone users. There also were studies examining the effects of these radio waves in animals and cells growing in petri dishes. The results are reassuring. There is no convincing evidence of any link between cellphone use and cancer or any other disease.”

    —Andrew Pollack in “Questions and Answers on the New Study Linking Cellphones and Cancer in Rats”, New York Times, May 27, 2016 

    Myth: Large studies such as the Million Women study and Danish study and petri dish studies reassure us there is no problem because they show no evidence.

    Fact: The Danish Cohort and Million Women study are two epidemiological cohort studies that are of poor quality in regards to understanding the effects of cell phone radiation and it is not possible to draw any scientifically reliable conclusions from either of them.

    • The Danish Cohort Study, originally funded by Danish Telecom, excluded corporate subscribers (the heavy cell phone users), has been heavily criticized by scientists including the International Agency for the Research on Cancer scientists.
    • The Million Women Study was not primarily designed to test the effect of cell phone radiation has been criticised for a short observation period, bias and crude exposure assessment.
    • The four year REFLEX studies, involving 12 groups from 7 European countries, studied the effects of radiation on animal and human cells in Petri dishes and  found GMS-modulated mobile phone radiation caused DNA strand breaks.
    Click here for a full explanation
    the new york times logo featured“Many studies have been conducted, including some very large ones like the Million Women Study in Britain, and a Danish study of more than 350,000 cellphone users. There also were studies examining the effects of these radio waves in animals and cells growing in petri dishes. The results are reassuring. There is no convincing evidence of any link between cellphone use and cancer or any other disease.”

    —Andrew Pollack in “Questions and Answers on the New Study Linking Cellphones and Cancer in Rats”, New York Times, May 27, 2016 

    Myth: Large studies such as the Million Women study and Danish study and petri dish studies reassure us there is no problem because they show no evidence.

    Fact:

    • Epidemiological cohort studies, like the Danish Cohort or Million Women study, are of poor quality and it is not possible to draw any scientifically reliable conclusions from them.
    • The Danish Cohort Study has been heavily criticized by scientists worldwide and was originally funded by Danish Telecom. Many scientists state that the design flaws invalidate the study’s conclusions. Why? Because the heavy cell phone users, more than 200,000 corporate subscribers, who used cell phones as part of their job, were placed in the control group. The study authors state, “Because we excluded corporate subscriptions, mobile phone users who do not have a subscription in their own name will have been misclassified as unexposed.” This bias explains why the 2011 World Health Organization IARC panel put less weight on the Danish study than on the Interphone and Hardell efforts. The International Agency for the Research on Cancer’s Robert Bann wrote that the exclusion of the corporate subscribers for the Danish Studies “seems remarkable” and “could have resulted in considerable misclassification in exposure assessment.”
    • The Million Women Study has been criticised for a short observation period, bias and crude exposure assessment. The researchers did not assess how much time the women spent on a cell phone either before or during the course of the study, so women who spent merely a few minutes almost every day at baseline would be lumped together with women who used their phone one half hour or more per day. Despite these major shortcomings, the study actually reported a statistically significant doubling of risk of acoustic neuroma, a tumor on the nerve from the ear to the brain, among those who had used their cell phone for 10 or more years.
    • Cohort cancer studies are only reliable if they adequately capture the long latency period for cancer development as well as the actual characteristic of cell phone use by individuals in these studies (e.g., use of speakers, head sets, frequency and duration of calls, type of phone, etc.). Exposure misclassifications in cohort studies such as those found in the Danish Cohort and Million Women study tend to increase the chances of a negative result.
    • The four year REFLEX studies, involving 12 groups from 7 European countries, studied the effects of radiation on animal and human cells in Petri dishes. They found GMS-modulated mobile phone radiation caused DNA strand breaks in isolated human fibroblasts and granulosa cells from rats and proved the presence of damage with the Comet Assay. Similar results were obtained with UMTS-modulated mobile phone radiation, the genotoxicity of which seems to be even higher than that of GSM. The NTP study used the same assay tests and found similar DNA damages in specific organs of the exposed male and female rats and mice.

    the new york times logo featuredIf they [cell phones] caused brain cancer in even a small percentage of users, we’d see an increase in its incidence. Since the late 1980s, however, the incidence of brain cancer in the United States has been decreasing.”

    —Aaron Carroll “Why It’s Not Time to Panic About Cell Phones and Cancer”, New York Times, May 31, 2016

    Myth: The lack of an epidemic of brain cancer demonstrates that cell phones pose no risk of brain cancer.

    Fact:

    • It will take decades to see an epidemic of brain cancer in the general population because brain tumors have a very long latency period.
    • The most aggressive types of brain cancers and those tumor types specifically associated with cell phone use (the types which NTP rats developed) are rising. These increases are only evident when you break down the statistics into specific tumor type rather than look at brain cancer rates overall.

    Case control research is a more valid study design than population trends at this time and these types of studies do show an association between cancer and cell phone use.

    Click here for a full explanation
    the new york times logo featuredIf they [cell phones] caused brain cancer in even a small percentage of users, we’d see an increase in its incidence. Since the late 1980s, however, the incidence of brain cancer in the United States has been decreasing.”

    —Aaron Carroll “Why It’s Not Time to Panic About Cell Phones and Cancer”, New York Times, May 31, 2016

    Myth: The lack of an epidemic of brain cancer demonstrates that cell phones pose no risk of brain cancer.

    Fact:

    • It will take decades to see an epidemic of brain cancer in the general population because brain tumors have a very long latency period. While cell phones have been around for decades, the majority of cellphone users have only recently become heavy users, so it is not likely that a large overall increase in incidence rates will have appeared yet.
    • In fact, the most aggressive types of brain cancers and those types specifically associated with cell phone use (the types which NTP rats developed) are rising. According to the American Brain Tumor Association’s largest, most comprehensive analysis to date, the incidence of the most aggressive gliomas (a category of brain tumors) are rising in adolescents and young adults within the US. The ABTA study shows increased yearly incidence of the following brain tumors: anaplastic astrocytoma, tumors of the meninges, tumors of the sellar region and unclassified tumors. Glioblastomas, the type of brain cancer found to be linked to cell phone radiation in the NTP study and in human studies, are increasing in those aged 15-39 in the United States. International registries have also indicated an increase (Zada et al, 2012, Danish Cancer Society Press Release, Ho et .al., 2014 and Dobes 2011). These increases are not evident in population based research studies when the incidence of all brain cancers “overall” are considered. These increases are only evident when you break down the statistics into specific tumor type.
    • Case control research is a more useful study design than population trends at this time and these studies do show an association between cancer and cell phone use. Population wide based studies are not the best way to assess the link between cellphones and cancer until at least another decade from now (cell phones and wireless have only fully saturated society for a little over a decade). Research looking at high-risk groups using case-control designs are more suited to showing cancer risk from cell phones and they have found an association. All independent research using case control design examining long term (greater than ten years) cell phone use have showed increases in brain cancer associated with long term cell phone use. 

    fortune logo 2016 840x485“That said, other studies have suggested cellphone radiation is safe. For example, a study in Australia, the results of which were released last month, showed no increase in brain cancer in the country that could be tied to the widespread rise in cellphone use.”

    David Meyer in “U.S. Government Study Links Cellphone Radiation With Cancer (In Rats)” Fortune, May 27, 2016

    Myth: A recent Australian study showed there is no rise in brain cancer so this NTP study must be bogus.

    Fact: This study is not proof of safety for multiple reasons.

    • This widely publicized article claiming that cell phones are safe by the Australian sociologist Simon Chapman has been critiqued by a series of published articles (Bandara 2016, Morgan 2016, Wojcik 2016) criticizing the analysis and study design.
    Click here for a full explanation
     
    fortune logo 2016 840x485“That said, other studies have suggested cellphone radiation is safe. For example, a study in Australia, the results of which were released last month, showed no increase in brain cancer in the country that could be tied to the widespread rise in cellphone use.”

    David Meyer in “U.S. Government Study Links Cellphone Radiation With Cancer (In Rats)” Fortune, May 27, 2016

    Myth: A recent Australian study showed there is no rise in brain cancer so this NTP study must be bogus.

    Fact:

    • The widely publicized article claiming that cell phones are safe by the Australian sociologist Simon Chapman has been critiqued by a series of published articles. Scientists are calling for a retraction of the Australian study because of a number of errors, false assumptions and cherry-picked data. Newly published appraisals (Bandara 2016, Morgan 2016, Wojcik 2016) debunk the claim by Chapman et. al. that “After nearly 30 years of mobile phone in Australia among millions of people, there is no evidence of any rise in any age-group that could be plausibly attributed to mobile phones.”
    • Examples of concerns raised about the study:
      • The paper referred to an Australian paper but failed to report the full statement that found a significant increasing incidence in glioblastoma.
      • The scientists also point out that Chapman does not analyze information on actual minutes of mobile phone use by a person, but rather estimates this based only on the number of mobile phone subscriptions.
      • Clinical director and forensic expert Damian Wojcik of New Zealand wrote that the Chapman study fails to take into account evidence that the locations of brain tumors that are increasing in the young are precisely those locations associated with mobile phones.
    “By showing only that part of the data that supports his view, Chapman is playing fast and loose with science and putting us all at grave risk,” stated Devra Lee Davis, “He basically ignores rising brain cancer rates in the U.S. and Australia that have grown rapidly in those under age 65 that have incurred the greatest use of phones for the longest time. Instead he points to the lack of an overall population increase in the disease as proof phones have no effect.”

    Overarching Myth 5: Experts overwhelmingly have discredited the study results and conclude it to be irrelevant.

    Fact: The majority of NIH scientific reviewers to the NTP dataset believe the findings are valid and that the radiation exposure is related to the cancer.

    losangelestimes“Several of them [NIH researchers] found significant shortcomings that they said called into question the strength of any link between radiation exposure and tumor growth.

    “I am unable to accept the author’s’ conclusions,” wrote Dr. Michael S. Lauer of the National Institutes of Health, a reviewer who conducted his own analysis of the data.”

    —Karen Kaplan, “Health experts question federal study linking cell phones to brain tumors, Los Angeles Times, May 27, 2016

    Myth: NIH’s own reviewers could not accept the study conclusions.

    Fact:

    • The majority of NIH scientific reviewers to the NTP dataset believe the findings are valid and that the radiation exposure is related to the cancer.
    • Dr. Lauer’s comments are incorrectly presented in news reports as representing the general tone of scientific reception to the study.
    • Dr. Michael Lauer’s criticisms were responded to with scientific Fact by NTP researchers and this is documented in the report as part of the review process.
    • Despite these facts, Dr. Michael Lauer’s comments have repeatedly and incorrectly been presented as evidence of a flawed study.
    Click here for a full explanation

    losangelestimes“Several of them [NIH researchers] found significant shortcomings that they said called into question the strength of any link between radiation exposure and tumor growth.

    “I am unable to accept the author’s’ conclusions,” wrote Dr. Michael S. Lauer of the National Institutes of Health, a reviewer who conducted his own analysis of the data.”

    —Karen Kaplan, “Health experts question federal study linking cell phones to brain tumors, Los Angeles Times, May 27, 2016

    Myth: NIH’s own reviewers could not accept the study conclusions.

    Fact: The majority of NIH scientists who reviewed the data agreed with the study conclusions.

    • Dr. Lauer’s comments are incorrectly presented as representing the general tone of scientific reception to the study. In fact, Dr. Lauer’s review comments were comprehensively and scientifically rebutted in the NTP report itself (in the section entitled NTP Responses to NIH Reviewer’s Comments, page 67-74). It is standard process to solicit peer reviews, then to explain the analysis or make changes if necessary in response to the critiques and this process is fully documented in the NTP report. The repeated presentation of Dr. Lauer’s review statements without explaining the review process and NTPs later response to the statements paints an inaccurate depiction of the scientific discourse on the study.
    • The majority of NIH scientific reviewers to the NTP dataset believe the findings are valid and that the radiation exposure is related to the cancer. The NTP study had three panels of reviewers rather than the usual one panel. Dr. John Bucher, Director of the National Toxicology Program Division, has repeatedly stated in his presentations of the NTP study that “the majority” of reviewers agreed with the analysis. Watch the NIEHS video presentation in June 2016.
    • Dr. Michael Lauer’s criticisms have been invalidated by not only the NTP (in their response to his statements) but also by experts.  
      • Dr. Melnick responded to one of Dr Lauer’s statements in the Hebrew University Press conference that “One comment was made that the study had low statistical power and that might lead to a false positive. I’m not sure if that was a misstatement by the reviewer because low statistical power means there’s a high probability of accepting the null hypothesis even when a true effect may exist. That is, there is a greater chance for a false negative rather than a false positive if there is low statistical power.”
    • Despite these facts, Dr. Michael Lauer’s comments have repeatedly and incorrectly been presented as evidence of a flawed study. The New York News article headline misleadingly states, “National Institutes of Health expert reviewers are finding flaws in the agency’s new study that connects heavy cell phone radiation to a slight increase in brain tumors in male rats.”

    fortune logo 2016 840x485

    “Dr. Aaron Carroll, a professor at the Indiana University School of Medicine, did a close reading of the study, (via Vox) and saw some things that should trigger skepticism.”

    David Z. Morris in “That Cell-Phone Cancer Study isn’t Quite As Scary as it Seems”, Fortune, May 29, 2016

    Myth: The New York Times review of the NTP study proves the study is bad.

    Fact: Dr. Carroll’s NYT column contained 8 serious false and misleading statements that have not been corrected. Yet now the non peer reviewed NYT article is referred to as evidence of NTP’s limitations.

    Click here for a full explanation
     

    fortune logo 2016 840x485

    “Dr. Aaron Carroll, a professor at the Indiana University School of Medicine, did a close reading of the study, (via Vox) and saw some things that should trigger skepticism.”

    David Z. Morris in “That Cell-Phone Cancer Study isn’t Quite As Scary as it Seems”, Fortune, May 29, 2016

    Myth: The New York Times review of the NTP study proves the study is bad.

    Fact: Dr. Carroll’s column contained 8 serious false and misleading statements prompting a response from Dr. Ronald Melnick, who led the NTP study’ design team. Dr. Melnick sent the New York Times a letter going point by point through Carroll’s column pointing out each of the false and misleading statements.The New York Times responded that “We do not see anything in the article that needs to be corrected” and did not print Dr. Melnick’s letter. The full email exchange between Dr. Melnick and the New York Times is available to read.

    • Dr. Carroll has no expertise in electromagnetic fields or understanding rat bioassays, and his misleading and non factual New York Times article was not peer reviewed science. Yet it is being presented as an “expert” opinion. In fact, Carroll’s research instead focuses on integrating information technology into health care. For example, he has published on the use of mobile phones in diabetes management, and issues in adopting health information technology and integrating computerized clinical decision support systems into clinical practice.
    • Caroll again cites the NTP study in a JAMA Forum opinion piece stating, “This is how we can have headlines proclaiming that cell phones cause cancer because of a new small study, regardless of how much data and evidence that we already have that don’t fit with those findings.” Such a statement seems to be referring to the NTP as a “new small study” yet again perpetuating myths about the study being small.

    linkedin logo svg“Fortunately the (NTP) report was quickly discredited by scientists due to the poor quality of the results – which failed to meet basic principles of toxicology and doubt about the relevance to human exposure especially in light of overwhelming epidemiology data which contradicts these findings.”

    —Michael Dellarco in “Fallout from the NTP Cell Phone Radiofrequency Radiation Study”, Linkedin, June 6, 2016

    Myth: The NTP study has been fully discredited by scientists and experts due to major flaws.  

    Fact: The majority of expert scientific responses to the NTP study respect the findings and the majority of NIH data reviewers agree with the conclusions of the report.

    • The National Toxicology Program (NTP) of The National Institutes of Health animal toxicology research is considered the “gold standard”.
    • A generalization that the NTP study is “discredited by scientists” is  false and misleading.
    Click here for a full explanation
     

    linkedin logo svg“Fortunately the (NTP) report was quickly discredited by scientists due to the poor quality of the results – which failed to meet basic principles of toxicology and doubt about the relevance to human exposure especially in light of overwhelming epidemiology data which contradicts these findings.”

    —Michael Dellarco in “Fallout from the NTP Cell Phone Radiofrequency Radiation Study”, Linkedin, June 6, 2016

    Myth: The NTP study has been fully discredited by scientists and experts due to major flaws.  

    Fact:

    • The National Toxicology Program (NTP) of The National Institutes of Health animal toxicology research is considered the “gold standard”. The NTP, established by Congress in 1978 is internationally renowned for its research and toxicological studies, which are used by federal and state regulatory agencies to protect the public from exposure to toxic and carcinogenic substances. Worldwide experts were brought in to validate the exposure setup. Statements that the NTP work is “poor quality” and “failing  to meet basic principles of toxicology” are unfounded at best.

    “This report from the National Toxicology Program is good science… they convened not one but three panels to look at abnormal tissues from treated animals to ensure that what was identified as a brain and heart tumor was indeed a brain and heart tumor; they solicited review from multiple scientists from outside the NTP to critically review all aspects of the data analysis and study findings, to ensure the findings would stand up to the critical assessment expected once these unexpected findings were released.” – Otis W. Brawley, M.D., American Cancer Society Chief Medical Officer

    • There is not “overwhelming epidemiology data which contradicts these findings” but quite the contrary. The findings of brain tumors (gliomas) and malignant schwann cell tumors of the heart in the NTP study present a major public health concern because these tumors occurred in the same types of cells in rodents that had been reported to develop into tumors in humans in several epidemiological studies of long term cell phone users.
    • A generalization that the NTP study is “discredited by scientists” is false and misleading. For example, the Bloomberg article was cited in the Linked-In post as proof of this despite the article being penned by Faye Flam, a columnist (not a scientist) who focuses on sex and evolution and her review of the NTP where she describes it as “just another study” with “just a few rats” propagates most of the myths addressed about the NTP study on this very page. The majority of NIH reviewers to the NTP study data agreed with the study conclusion.
    • Read responses to the NTP study by experts:

    Dr. Otis W. Brawley, Chief Medical Officer of the  American Cancer Society

    Dr. Jennifer A. Lowry, Chair of the  American Academy of Pediatrics  Council on Environmental Health Executive Committee

    Dr. Elisabeth Cardis, the Barcelona Institute for Global Health

    Dr. Franz Adlkofer,  the Pandora Foundation

    Dr. Joel Moskowitz , University of California at Berkeley

    Dr. Gautam Khurana, CNS Neurosurgery

    Dr. Dariusz Leszczynski, Chief Editor of ‘Radiation and Health’

    Dr. Chris Portier, former Director of the Environmental Toxicology Program (ETP) at the NIEHS and Associate Director of the  NTP

    EMF Scientists Appeal, 223 scientists that have published in the field

    Dr. Eitan Kerem, Chair  of Pediatrics, Hadassah Hebrew University Hospital

    “For years, the understanding of the potential risk of radiation from cell phones has been hampered by a lack of good science. This report from the National Toxicology Program (NTP) is good science.”Otis W. Brawley, M.D., American Cancer Society Chief Medical Officer

    • The majority of NIH scientific reviewers to the NTP dataset believe the findings are valid and that the radiation exposure is related to the cancer. The NTP study had three panels of reviewers rather than the usual one panel. Dr. John Bucher, Director of the National Toxicology Program Division, has repeatedly stated in his presentations of the NTP study that “the majority” of reviewers agreed with the analysis. Watch this stated in the NIEHS video presentation in June 2016. 

    Overarching Myth 5: This study still needs to be replicated before it will have an impact on federal regulations or health recommendations to the public.

    Fact: This $25 Million dollar study one of the most elaborate studies of any potentially hazardous exposure ever conducted. The concordance between the NTP study and human epidemiological studies is stunning and should guide federal agencies to issue protective policy and strong recommendations to reduce exposure.

    “It’s way too soon to take these findings as a reason to toss your phone out the window. We’ve explained before that single studies are basically useless on their own (here’s why) and that’s still the case. This research will almost certainly inspire new projects that try to replicate the troubling results, and that’s great. But when publications blast every contrarian new finding as a groundbreaking absolute truth, it makes the public less able to develop informed opinions.”

    Rachel Feltman in “Do cellphones cause cancer? Don’t believe the hype”, Washington Post, May 27, 2016 

    “But the weight of evidence is not in agreement with this small signal that has been found in rats. Until similar results are replicated in people, there isn’t a great deal to worry about.”

    —Michael Reilly in “A Connection between Cell Phones and Cancer Has Been Found. Should We Be Worried?”, MIT Technology Review, May 27, 2016

    Myth: This study needs to be replicated first- until then, it will not have an impact.

    Fact: This $25 Million dollar study one of the most elaborate and expensive studies of any potentially hazardous exposure ever conducted.

    • It will likely not be repeated as the exposure equipment has been dismantled.
    • The concordance between the NTP study and human epidemiological studies is stunning.
    • In addition, NTP also reported statistically significant evidence of DNA damage in mice as well as in rats.
    Click here for a full explanation

    “It’s way too soon to take these findings as a reason to toss your phone out the window. We’ve explained before that single studies are basically useless on their own (here’s why) and that’s still the case. This research will almost certainly inspire new projects that try to replicate the troubling results, and that’s great. But when publications blast every contrarian new finding as a groundbreaking absolute truth, it makes the public less able to develop informed opinions.”

    Rachel Feltman in “Do cellphones cause cancer? Don’t believe the hype”, Washington Post, May 27, 2016 

    “But the weight of evidence is not in agreement with this small signal that has been found in rats. Until similar results are replicated in people, there isn’t a great deal to worry about.”

    —Michael Reilly in “A Connection between Cell Phones and Cancer Has Been Found. Should We Be Worried?”, MIT Technology Review, May 27, 2016

    Myth: This study needs to be replicated first- until then, it will not have an impact.

    Fact: This $25 Million dollar study one of the most elaborate and expensive studies of any potentially hazardous exposure ever conducted. It will likely not be repeated as the exposure equipment has been dismantled. The concordance between the NTP study and human epidemiological studies is stunning.  In addition, NTP also reported statistically significant evidence of DNA damage in mice as well as in rats.  

    • This is one of the most elaborate and expensive studies of any potentially hazardous exposure ever conducted. It will likely not be repeated and there is little scientific reason to do so. The history of science is rich with single studies that have changed our way of thinking. Most importantly, the concordance between the NTP study and human epidemiological studies that have found evidence of a cancer risk (with the same types of cancers shown in the NTP rats) is stunning. The NTP study cost $25 million dollars. There is nothing small about it. It is the largest, most thorough and meticulously conducted animal study ever conducted. The design of the NTP study was presented at an annual meeting of the Bioelectromagnetics Society prior to the start of the NTP study and Ron Melnick PhD states of that day, “the overwhelming opinion expressed by the meeting participants was that this would be the largest and most comprehensive study in animals exposed to cell phone radiation, and that the results from this study would trump all other animal carcinogenicity studies of this agent.”
    • The results show a significant effect of DNA damage. Not only did cancer rates significantly increase in male rats, the NTP also reported statistically significant evidence of DNA damage from nonthermal exposure to cellphone radiation in mice as well as in rats. (male rats: frontal cortex, hippocampus, liver, blood; male mice: frontal cortex; female rats: frontal cortex; female mice: liver, blood.)
    • The NTP study will never be replicated as the exposure equipment no longer exists. The reverberation chambers have been dismantled.  The NTP equipment, design and costs associated with validating the radiofrequency exposures cost roughly 10 million dollars alone.

    “Given the lack of evidence for an increased incidence of brain tumors in the population in recent decades, I do not expect health agencies to react very strongly to these findings.”

    —Kenneth Foster in “U.S. Cellphone Study Fans Cancer Worries”, Wall Street Journal, May 28 2016

    Myth: The NTP study is not groundbreaking and will have little impact on federal health agency recommendations.

    Fact: The NTP report marks a paradigm shift in our understanding of radiation and cancer risk.

    • The NTP report will have  an impact on federal health and safety agency recommendations because it shows that federal radiation exposure limits are based on a flawed assumption.

    The NTP findings indicate our federal exposure limits are not protective of human health. If cell phone radiation were safe then we should have seen no effect from these exposures. The NTP tested the hypothesis that low level cell phone radiation -at non thermal levels-  could not cause health effects. Yet a health effect was shown.This is groundbreaking because US government exposure limits are based on the now disproved hypothesis that non-thermal effects are benign. The study results clearly show that cell phone radiation can cause adverse health effects at nonthermal levels. In order to adequately protect the public, federal agencies should now reassess federal exposure limits to protect the public from non thermal effects.

    “The NTP report linking radiofrequency radiation (RFR) to two types of cancer marks a paradigm shift in our understanding of radiation and cancer risk” and “This new evidence will undoubtedly factor into ongoing assessments by regulators to determine the potential cancer risk posed by cell phones. The American Cancer Society eagerly awaits guidance from government agencies, like the U.S. Food and Drug Administration (FDA) and the Federal Communications Commission (FCC), about the safety of cell phone use.”

    The American Cancer Institute Press Release

    “Despite what some outlets reported, this was a not-yet-published study of rats that had been shopped for “review,” but had not been accepted by any editors.”

    —Aaron Carroll “Why It’s Not Time to Panic About Cell Phones and Cancer”, New York Times, May 31, 2016

    Myth: The NTP study was not peer reviewed and was rejected by medical journals.

    Fact: The NTP Report was extensively peer reviewed by experts before the findings were released.

    • The peer reviews resulted in revisions to the NTP report which incorporated and addressed reviewer comments.
    • The NTP study will generate  numerous published papers and these prepared manuscripts are listed in the NTP Technical Report.
    Click here for a full explanation

    “Despite what some outlets reported, this was a not-yet-published study of rats that had been shopped for “review,” but had not been accepted by any editors.”

    —Aaron Carroll “Why It’s Not Time to Panic About Cell Phones and Cancer”, New York Times, May 31, 2016

    Facts:

    • The NTP findings were reviewed by expert peer reviewers selected by NTP and the National Institutes of Health. These expert reviewers gave comments included as appendices to the NTP report, and  as a result revisions to the current document incorporated and addressed these comments. Page 32 of the NTP Report lists the reviewers:
      • Diana C. Haines, D.V.M., Frederick National Laboratory
      • Michael S. Lauer, M.D., Office of Extramural Research, NIH
      • Maxwell P. Lee, Ph.D., Laboratory of Cancer Biology and Genetics, NCI,
      • Aleksandra M. Michalowski, M.Sc., Ph.D., Laboratory of Cancer Biology and Genetics, NCI
      • R. Mark Simpson, D.V.M., Ph.D., Laboratory of Cancer Biology and Genetics, NCI
      • Sixth reviewer’s name and comments are withheld.
    • The NTP also clearly states the charge of these reviewers is to peer review:

    “Charge: To peer review the draft report, statistical analyses, and pathology data and comment on whether the scientific evidence supports NTP’s conclusions) for the study findings.”

    • The NTP also extensively involved outside pathologists including pathologists with extensive experience in human brain tumors.

    They solicited review from multiple scientists from outside the NTP to critically review all aspects of the data analysis and study findings, to ensure the findings would stand up to the critical assessment expected once these unexpected findings were released.” – Otis W. Brawley, M.D., American Cancer Society Chief Medical Officer

    • The NTP typically publishes results of toxicology studies in detailed technical reports. These reports are available on the NIEHS site.
    • The NTP study will likely result in numerous published papers in medical journals and several manuscripts are being prepared for publication. The NTP Report states:

    “These manuscripts describe in detail the designs and performance of the RFR exposure system, the dosimetry of RFR exposures in rats and mice, the results to a series of pilot studies establishing the ability of the animals to thermoregulate during RFR exposures, and studies of DNA damage.”

    • Capstick M, Kuster N, Kühn S, Berdinas-Torres V, Wilson P, Ladbury J, Koepke G, McCormick D, Gauger J, Melnick R. A radio frequency radiation reverberation chamber exposure system for rodents.
    • Yijian G, Capstick M, McCormick D, Gauger J, Horn T, Wilson P, Melnick RL and Kuster N. Lifetime dosimetric assessment for mice and rats exposed to cell phone radiation.
    • Wyde ME, Horn TL, Capstick M, Ladbury J, Koepke G, Wilson P, Stout MD, Kuster N,  Melnick R, Bucher JR, and McCormick D. Pilot studies of the National Toxicology Program’s cell phone radiofrequency radiation reverberation chamber exposure system.
    • Smith-Roe SL, Wyde ME, Stout MD, Winters J, Hobbs CA, Shepard KG, Green A, Kissling GE, Tice RR, Bucher JR, Witt KL. Evaluation of the genotoxicity of cell phone radiofrequency  radiation in male and female rats and mice following subchronic exposure.
    • (Page 2 of the NTP Report)
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